Computation, Modeling & Signal Processing

Computation, Modeling & Signal Processing research topics include: neuroengineering to map and modify neural signaling; quantitative mechanobiology to reveal how physical forces and changes in the mechanics of cells and their environment drives cell signaling and responses; biological dynamics to describe and understand time varying biological systems; and the development of enabling methods such as quantitative image processing, machine learning and signal processing algorithms.

Affiliated Researchers

Marley Dewey

Assistant Professor of Bioengineering

The Dewey Lab engineers biomaterials with extracellular vesicles towards skeletal repair. Specifically, we examine a new class of extracellular vesicle residing in the extracellular matrix, termed matrix-bound nanovesicles. Using these tools we answer basic science questions and create translational therapies related to bone cancer, improving bone repair, preventing bone infection, and repairing coral reefs.

Cell, Tissue & Device Engineering

Computation, Modeling & Signal Processing

Siddharth Dey

Associate Professor of Bioengineering

Associate Professor of Chemical Engineering

The goal of our lab is to develop novel single-cell sequencing technologies to understand how variability in the epigenome regulates gene expression heterogeneity and cell fate decisions.

Synthetic & Systems Biology

Cell, Tissue & Device Engineering

Computation, Modeling & Signal Processing

Dorit Hanein

Professor of Bioengineering

Professor of Chemistry and Biochemistry

The Hanein Lab is exploring the structural functional complexities of the macromolecular machines that drive our biological processes—this includes imaging them in three-dimension and high resolution while at work in isolation, as well as within cells, organoids and tissues.

Computation, Modeling & Signal Processing

Synthetic & Systems Biology

Cell, Tissue & Device Engineering

Arnab Mukherjee

Assistant Professor of Bioengineering

Assistant Professor of Chemical Engineering

Our research focuses on engineering genetic reporters for imaging what we think of as the "dark matter" of biology - living systems that cannot be readily imaged using existing reporter gene techniques.

Synthetic & Systems Biology

Computation, Modeling & Signal Processing

Michelle O'Malley

Professor of Bioengineering

Professor of Chemical Engineering

Scholle Chair in Chemical Engineering

Genetic engineering and synthetic biology of non-model microorganisms.

Synthetic & Systems Biology

Computation, Modeling & Signal Processing

Kevin Plaxco

Professor of Chemistry & Biochemistry

Professor of Bioengineering

Biomolecular Science and Engineering Program

In-vivo molecular measurements, anyone?

Computation, Modeling & Signal Processing

Synthetic & Systems Biology

Cell, Tissue & Device Engineering

Beth L. Pruitt

Professor and Chair of Bioengineering

Professor of Mechanical Engineering

Director, NSF Research Training Program in Data Driven Biology

Director, NIH T32 Training Program in Quantitative Mechanobiology

Biomolecular Science and Engineering Program

The Pruitt Lab studies how mechanics mediates biological signaling using microtechnologies for cellular mechanobiology and mechanical measurements.

Cell, Tissue & Device Engineering

Computation, Modeling & Signal Processing

Omar Saleh

Professor

Materials

Saleh's research is focused on the molecular physics underlying biological systems, with particular experience in nucleic acids, protein/DNA interactions, biomolecular elasticity, and self-assembled biomolecular systems.

Computation, Modeling & Signal Processing

Synthetic & Systems Biology