Research in mechanobiology seeks to reveal how physical forces and changes in the mechanics of cells and their environment drives cell signaling and responses. Mechanical properties change during development, cell differentiation, physiology, and disease and mechanical deformations of cell and biomaterials can change cell signaling and properties to drive long range coordination cell behavior and responses to mechanical loading. Researchers are building new methods and models to understand how to measure and control the mechanical environment and developing models relating tissue structure and function and chemo-mechanical signaling.