Theogarajan is interested in the marriage between materials, electronics and micro/nanofabrication as a means of developing new devices and tools for medical applications. He believes that a truly synergistic collaboration between these fields will lead to novel methods to solve biomedically relevant problems.
''One focus of Theogarajan’s research is on the development of CMOS-enabled nanoscale sensors. His group is exploring the potential of nanopore devices integrated within a CMOS platform for DNA sequencing; by cointegrating electronics with the nanopore, noise is lowered and bandwidth is enhanced. Furthermore, integrating electronics in close proximity to the nanopore opens up the possibility of closed-loop feedback to enhance the dynamic range. Theogarajan is currently expanding on this sensing platform to enable general biomolecule detection by exploiting the recognition properties of aptamers.
Another research focus is on the development of neural prosthetic devices. Theogarajan’s group is exploring the possibility of using ionic stimulation of neurons as a safer alternative to electronic stimulation, and developing novel materials that can be used as synthetic ion pumps in an electronically controlled hybrid device.