CBE/ENGR 225 Faculty Seminar Series Presents: Ellen M. Sletten, Ph.D., Assistant Professor & John McTague Career Development Chair, Department Chemistry & Biochemistry, UCLA, Tues., Nov.13, 2018

Tuesday, November 13, 2018 in ESB 2001 @ 11am-12pm

Ellen M. Sletten, Ph.D.

Assistant Professor & John McTague Career Development Chair

Department Chemistry & Biochemistry

University of California, Los Angeles


Tuesday, November 13, 2018 @ 11am-12pm

ESB 2001

*Light refreshments will be provided*


Host: Otger Campas, Ph.D.

Versatile Perfluorocarbon Nanotheranostics


 Nanomaterials that sequester, protect, and delivery therapeutics are necessary to combat complex diseases.  The Sletten Group employs perfluorocarbon (PFC) nanoemulsions as a core delivery scaffold.  PFC emulsions are non-toxic, dynamic nanomaterials that have been previously employed as oxygen carriers and contrast agents. We leverage the orthogonal nature of the fluorous phase to, in one step, prepare multifunctional nanomaterials with fluorous-tagged therapeutics/diagnostics loaded on the inside and targeting agents appended to the outside. This talk will discuss optimization of the surfactant to control the biodistribution, cellular internalization, and triggered disassembly of the droplets.  Additionally, the versatility of the system will be showcased by highlighting therapeutic and diagnostic applications of droplets loaded with fluorophores, photosensitizers, and chemotherapeutics.