CBE/ENGR 225 Seminar Presents: Carolina Arias, Assistant Professor, Dept. of MCDB, University of California, Santa Barbara

Tues., May 30, 2017 @ 4pm in ESB #2001

Carolina Arias, Ph.D.

Assistant Professor

Department of Molecular, Cellular, and Developmental Biology

University of California, Santa Barbara


Tuesday, May 30, 2017

4:00 pm

ESB, Room #2001

*Cookies and Coffee will be provided*

When Tinkerers Become Engineers: Viral Control of the Host Protein Synthesis Machinery 

As obligate intracellular parasites, viruses rely strictly on their hosts for the synthesis of the molecular building blocks they need for their replication. The viral dependence on the host molecular machineries to translate and fold their proteins during infection, results in a tug of war between cells and viruses for the limiting factors required for protein synthesis. Our knowledge of the complex strategies used by both RNA and DNA viruses to subvert their host’s protein synthesis and quality control apparatus has grown over the past decades, yet many pressing questions still remain. How do viruses manipulate the numerous cellular factors involved in translation? And once their proteins are made, how do they exploit and remodel the cellular pathways required for proper protein folding and quality control? The emergence and refinement of system level technologies, and the availability of new chemical matter to modulate translation initiation and protein quality control offer an unprecedented opportunity to broaden our knowledge of viral and cellular physiology, ultimately providing new fertile ground for developing therapeutics for viral infections.