CBE/ENGR 225 Faculty Seminar: Steve Trainoff, Chief Scientist, Wyatt Technology Corporation

Tuesday, October 25, 2016 @ 4pm in ESB, room #2001

Steven Trainoff, Ph.D.

Chief Scientist, Wyatt Technology Corporation 

Tuesday, October 25, 2016

4:00 pm

ESB, Room #2001

*Light refreshments will be provided*           

Free Solution Electrophoretic Mobility Detection as Tool for

Characterizing Nanoparticle Stability 


Interfacial potential has long been understood to play a key role in the stability of colloids and emulsions. Instruments that determine the zeta potential through measurements of electrophoretic mobility are indispensable tools for characterizing the particle charge and are used to guide efforts to control stability.  In recent years the explosion of nanoparticle applications have challenged instruments that were designed for colloid analysis.  This talk will discuss the challenges of mobility detection of nanoparticles and how they are addressed with the Wyatt Mobius.  With 31 parallel detector channels it effectively suppresses diffusion and gives rapid and accurate mobility measurements over an enormous dynamic range: from molecular samples with down to 1 nm up to particles that are tens of µm.  The parallel detection technique allows the use of low applied fields that do not damage delicate samples.  It also has an integrated dynamic light scattering detector that simultaneously measures the hydrodynamic size distribution.   Sample collection can be automated with an auto-sampler to allow unattended operation.  Applications presented will include characterization of drug conjugates, vaccine adjuvants, and gold nanoparti