CBE/ENGR 225 Faculty Seminar Series Presents: Adriana Dawes, Ph.D., Associate Professor, The Ohio State University, Dept. of Mathematics, Department of Molecular Genetics, Tues., Feb.13, 2018

Tues., February 13, 2018, ESB #2001

Adriana Dawes, Ph.D.
Associate Professor
The Ohio State University
Department of Mathematics
Department of Molecular Genetics

 Tuesday, February 13, 2018
ESB #2001
*Light refreshments will be provided*

Host: Megan Valentine

Centrosome Positioning in the Early C. Elegans Embryo: Torque Generation in a Radially Symmetric Cell

ABSTRACT: Asymmetric cell division, where daughter cells inherit unequal amounts of specific factors, is critical for development and cell fate specification. Asymmetric cell division occurs in polarized cells as a result of positioning the centrosomes along the polarity axis. Using an individual-based stochastic model of microtubule dynamics and experiments in the early C. elegans embryo, we explore potential sources of cortical force generation and demonstrate the potential role of both cortical and centrosomal asymmetries for recapitulating the in vivo dynamics and proper positioning of the centrosomes.