CBE/ENGR 225 Faculty Seminar: Prof Michael J. Mahan, Dept of Molecular, Cellular, and Developmental Biology, UCSB
Michael J. Mahan, Ph.D.
Professor, Department of Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Tuesday, September 27, 2016
ESB, Room #2001
*Cookies and Coffee will be provided*
People Are Not Petri Dishes: Why Antibiotics Fail
Physicians rely on laboratory antimicrobial susceptibility testing of clinical isolates to identify a suitable antibiotic for therapy. Although the recommended antibiotics clear most bacterial infections, some patients fail to respond and require prolonged therapy, higher dosing or different antibiotics. Why does this occur and what are the possible implications? By studying antibiotic resistance in the context of infection, we identified a host-dependent mechanism that promotes antibiotic resistance at concentrations of drug that far exceed dosages determined by standardized antimicrobial testing.These findings question current antibiotic testing methods that have guided physician treatment practices and drug development for the last several decades.